{"id":2289,"date":"2023-04-10T00:15:50","date_gmt":"2023-04-09T17:15:50","guid":{"rendered":"https:\/\/hienbacsi.com\/?p=2289"},"modified":"2025-04-10T13:36:14","modified_gmt":"2025-04-10T06:36:14","slug":"vi-sao-te-bao-beta-tuy-ngay-cang-giam-gay-mat-kiem-soat-duong-huyet-o-benh-nhan-dai-thao-duong-tip-2","status":"publish","type":"post","link":"https:\/\/hienbacsi.com\/index.php\/2023\/04\/10\/vi-sao-te-bao-beta-tuy-ngay-cang-giam-gay-mat-kiem-soat-duong-huyet-o-benh-nhan-dai-thao-duong-tip-2\/","title":{"rendered":"V\u00ec sao t\u1ebf b\u00e0o beta tu\u1ef5 ng\u00e0y c\u00e0ng gi\u1ea3m g\u00e2y m\u1ea5t ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng t\u00edp 2?"},"content":{"rendered":"\n

ThS BS Tr\u1ea7n H\u1eefu Hi\u1ec1n<\/strong><\/p>\n\n\n\n

T\u1ed1t nghi\u1ec7p b\u1eb1ng DIU \u0110H CORSE C\u1ed9ng Ho\u00e0 PH\u00c1P<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

5 c\u01a1 ch\u1ebf b\u1ec7nh sinh t\u00e1c \u0111\u1ed9ng qu\u00e1 tr\u00ecnh gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o beta trong tu\u1ef5 c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2:<\/p>\n\n\n\n

1. Stress oxi h\u00f3a: T\u0103ng m\u1ee9c \u0111\u01b0\u1eddng huy\u1ebft li\u00ean t\u1ee5c trong \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2 d\u1eabn \u0111\u1ebfn t\u0103ng s\u1ea3n xu\u1ea5t c\u00e1c g\u1ed1c t\u1ef1 do trong t\u1ebf b\u00e0o beta. \u0110\u00e2y l\u00e0 m\u1ed9t nguy\u00ean nh\u00e2n g\u00e2y stress oxi h\u00f3a, g\u00e2y t\u1ed5n th\u01b0\u01a1ng cho c\u00e1c t\u1ebf b\u00e0o beta v\u00e0 gi\u1ea3m kh\u1ea3 n\u0103ng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a ch\u00fang.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

2. D\u1ef1 tr\u1eef m\u1ee1 v\u00e0 gluxit trong t\u1ebf b\u00e0o beta: S\u1ef1 t\u00edch t\u1ee5 qu\u00e1 m\u1ee9c c\u1ee7a m\u1ee1 v\u00e0 gluxit trong t\u1ebf b\u00e0o beta do ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng kh\u00f4ng l\u00e0nh m\u1ea1nh, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u0103n qu\u00e1 nhi\u1ec1u \u0111\u01b0\u1eddng v\u00e0 m\u1ee1, l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o beta. S\u1ef1 d\u01b0 th\u1eeba c\u1ee7a m\u1ee1 v\u00e0 gluxit trong t\u1ebf b\u00e0o beta c\u0169ng g\u00e2y ra stress oxi h\u00f3a v\u00e0 t\u1ed5n th\u01b0\u01a1ng cho c\u00e1c t\u1ebf b\u00e0o beta.<\/p>\n\n\n\n

3. K\u00edch th\u00edch mi\u1ec5n d\u1ecbch: H\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch c\u00f3 th\u1ec3 ph\u1ea3n \u1ee9ng v\u1edbi c\u00e1c protein t\u1ef1 di\u1ec5n ra trong t\u1ebf b\u00e0o beta, g\u00e2y vi\u00eam v\u00e0 t\u1ed5n th\u01b0\u01a1ng cho ch\u00fang. \u0110\u00e2y l\u00e0 m\u1ed9t nguy\u00ean nh\u00e2n kh\u00e1c g\u00e2y gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o beta trong tu\u1ef5 c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2.<\/p>\n\n\n\n

4. Trong m\u00f4i tr\u01b0\u1eddng \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2, c\u00e1c t\u1ebf b\u00e0o beta c\u00f3 th\u1ec3 m\u1ea5t t\u00ednh \u0111\u1eb7c tr\u01b0ng c\u1ee7a ch\u00fang v\u00e0 tr\u1edf th\u00e0nh t\u1ebf b\u00e0o c\u00f3 t\u00ednh bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o alpha (t\u1ebf b\u00e0o s\u1ea3n xu\u1ea5t glucagon) ho\u1eb7c t\u1ebf b\u00e0o epsilon (t\u1ebf b\u00e0o s\u1ea3n xu\u1ea5t somatostatin). \u0110i\u1ec1u n\u00e0y l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng ti\u1ebft insulin c\u1ee7a c\u00e1c t\u1ebf b\u00e0o beta.<\/p>\n\n\n\n

5. M\u1ea5t kh\u1ea3 n\u0103ng \u0111\u00e1p \u1ee9ng insulin: C\u00e1c t\u1ebf b\u00e0o beta trong tu\u1ef5 c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2 c\u00f3 th\u1ec3 m\u1ea5t \u0111i kh\u1ea3 n\u0103ng \u0111\u00e1p \u1ee9ng insulin, t\u1ee9c l\u00e0 kh\u00f4ng th\u1ec3 t\u1ea1o ra \u0111\u1ee7 insulin \u0111\u1ec3 \u0111\u00e1p \u1ee9ng v\u1edbi nhu c\u1ea7u c\u1ee7a c\u01a1 th\u1ec3.<\/p>\n\n\n\n

T\u00e0i li\u1ec7u tham kh\u1ea3o<\/strong><\/p>\n\n\n\n

1. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003 Mar;52(3):102-10. doi: 10.2337\/diabetes.52.3.102. (Ngu\u1ed3n: https:\/\/pubmed.ncbi.nlm.nih.gov\/12606522\/<\/a>)<\/p>\n\n\n\n

2. Cnop M, Welsh N, Jonas JC, J\u00f6rns A, Lenzen S, Eizirik DL. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes. 2005 Jul;54 Suppl 2:S97-S107. doi: 10.2337\/diabetes.54.suppl_2.s97. (Ngu\u1ed3n: https:\/\/pubmed.ncbi.nlm.nih.gov\/15920037\/<\/a>)<\/p>\n\n\n\n

3. Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest. 2006 Jul;116(7):1802-12. doi: 10.1172\/JCI28658. (Ngu\u1ed3n: https:\/\/pubmed.ncbi.nlm.nih.gov\/16823477\/<\/a>)<\/p>\n\n\n\n

4. Weir GC, Bonner-Weir S. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes. 2004 Dec;53 Suppl 3:S16-21. doi: 10.2337\/diabetes.53.suppl_3.S16. (Ngu\u1ed3n: https:\/\/pubmed.ncbi.nlm.nih.gov\/15561907\/<\/a>)<\/p>\n\n\n\n

5. Maedler K, Donath MY. Beta-cells in type 2 diabetes – a loss of function and mass. Horm Metab Res. 2004 Oct;36(10):692-705. doi: 10.1055\/s-2004-826167. (Ngu\u1ed3n: https:\/\/pubmed.ncbi.nlm.nih.gov\/15543971\/<\/a>)<\/p>\n\n\n\n

6. Rhodes CJ. Type 2 diabetes-a matter of beta-cell life and death? Science. 2005 Feb 25;307(5709):380-4. doi: 10.1126\/science.1104345. (Ngu\u1ed3n: https:\/\/pubmed.ncbi.nlm.nih.gov\/15662003\/<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"

ThS BS Tr\u1ea7n H\u1eefu Hi\u1ec1n T\u1ed1t nghi\u1ec7p b\u1eb1ng DIU \u0110H CORSE C\u1ed9ng Ho\u00e0 PH\u00c1P 5 c\u01a1 ch\u1ebf b\u1ec7nh sinh t\u00e1c \u0111\u1ed9ng qu\u00e1 tr\u00ecnh gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o beta trong…<\/p>\n","protected":false},"author":1,"featured_media":3267,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[49,17,47],"tags":[59,62],"jetpack_featured_media_url":"https:\/\/hienbacsi.com\/wp-content\/uploads\/2025\/04\/img_7213-1.jpg","_links":{"self":[{"href":"https:\/\/hienbacsi.com\/index.php\/wp-json\/wp\/v2\/posts\/2289"}],"collection":[{"href":"https:\/\/hienbacsi.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hienbacsi.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hienbacsi.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hienbacsi.com\/index.php\/wp-json\/wp\/v2\/comments?post=2289"}],"version-history":[{"count":5,"href":"https:\/\/hienbacsi.com\/index.php\/wp-json\/wp\/v2\/posts\/2289\/revisions"}],"predecessor-version":[{"id":3269,"href":"https:\/\/hienbacsi.com\/index.php\/wp-json\/wp\/v2\/posts\/2289\/revisions\/3269"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hienbacsi.com\/index.php\/wp-json\/wp\/v2\/media\/3267"}],"wp:attachment":[{"href":"https:\/\/hienbacsi.com\/index.php\/wp-json\/wp\/v2\/media?parent=2289"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hienbacsi.com\/index.php\/wp-json\/wp\/v2\/categories?post=2289"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hienbacsi.com\/index.php\/wp-json\/wp\/v2\/tags?post=2289"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}